Glucocorticoids adrenal cortex3/23/2023 ![]() However, whether there are independent effects among subtypes of ELS remains unclear. Molecular studies indicate that, in general, the hereditary character of psychiatric disorders is polygenic, multifactorial and highly complex, with innumerable low-effect genetic variants interacting with each other. Furthermore, research has suggested a relationship between early life stress and depression, particularly more prolonged episodes of depression with treatment-resistant outcomes. During the most critical development period (childhood and adolescence), these changes increase the risk of having child-onset psychiatric disorders. Exhaustive research has shown that ELS leads to physiological changes, such as alteration in the HPA axis. Among these factors, early life stress (ELS), including sexual, physical, emotional abuse, and emotional and physical neglect, enhances the odds of having menial conditions throughout life. Different factors are essential in increasing the vulnerability to psychiatric disorders, such as genetics. ![]()
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